고혈압을 동반한 만성 치주염 환자의 치은 조직에서 C-reactive protein과 macrophage colony-stimulating factor의발현
The expressions of C-reactive protein and macrophage colony-stimulating factor in gingival tissue of human chronic periodontitis with hypertension
김철우, 박진우, 서조영, 이재목, 조제열,
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김철우 ( Kim Cheol-Woo ) - 경북대학교 치의학전문대학원 치주과학교실
박진우 ( Park Jin-Woo ) - 경북대학교 치의학전문대학원 치주과학교실
서조영 ( Suh Jo-Young ) - 경북대학교 치의학전문대학원 치주과학교실
이재목 ( Lee Jae-Mok ) - 경북대학교 치의학전문대학원 치주과학교실
조제열 ( Cho Je-Yoel ) - 경북대학교 치의학전문대학원 구강생화학교실
KMID : 0363020090390040391
Abstract
Purpose: The purpose of this study was to quantify and compare the expressions of CRP and M-CSF in the gingival tissues of the patients with chronic periodontitis associated to hypertension.
Methods: Gingival tissue samples were obtained during periodontal surgery or tooth extraction. Clinically healthy gingival tissue samples from systemically healthy 12 patients were categorized as group 1 (n=12). Inflammatory gingival tissue samples from patients with chronic periodontitis were categorized as group 2 (n=12). Inflammatory gingival tissue samples from patients with chronic periodontitis associated with hypertension were categorized as group 3 (n=12). Tissue samples were prepared and analyzed by Western blotting. The quantification of CRP and M-CSF were performed using a densitometer and statistically analyzed by one-way ANOVA followed by Tukey test.
Results: There were significant differences between group 1 and group 2 and between group 1 and group 3 in both CRP and M-CSF. The differences between group 2 and group 3 were not statistically significant in both proteins. However, the expression levels of CRP and M-CSF in hypertensive inflammatory gingiva showed increased tendency compared to non-hypertensive inflammatory gingiva.
Conclusions: It is suggested that CRP and M-CSF might be used as inflammatory and bone resorption markers in periodontal diseased tissue. It is assumed that hypertension may be associated with the progression of periodontal inflammation and alveolar bone resorption.
키워드
chronic periodontitis;C-reactive protein;hypertension;macrophage colony-stimulating factor
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